How It Works
A lot of research went into creating our patent-pending supplement. After examining precedent studies on hangovers, we conducted our own trials on a test panel to determine the most effective grouping of nutrients for combating the identified causes of a hangover.
Many of the body’s basic natural processes are overwhelmed by large quantities of alcohol, and as a result the body is unable to carry on their usual functions and key nutrients are depleted. Our dietary supplement helps restore balance and function to the body, allowing it to return to normal after a night of drinking by attacking the four underlying causes of hangover symptoms
Underlying causes of a hangover
There are four main contributors that have been identified by scientific research: 1) acetaldehyde buildup, 2) glutamine rebound, 3) immunologic disturbances, and 4) vitamin and electrolyte loss.
1. Acetaldehyde buildup
Acetaldehyde significantly contributes to hangovers. As ethanol is broken down in the liver, this toxic molecule is created, wreaking havoc on the body. This acetaldehyde is up to 30 times more toxic than ethanol. Acetaldehyde also interferes with functions of other molecules through a process called “cross-linking.”
2. Inflammatory Immune Response
Immunologic disturbances may occur from excess alcohol consumption as the body reacts to its toxic effects. Alcohol triggers your immune system to produce an inflammatory reaction. One major sign of this process is the overproduction of cytokines, essentially the body’s immune system in overdrive, which causes physical and mental discomfort.
Increased cytokines contribute not only to the discomfort of hangovers (aching and malaise), but also to the more cognitive hangover effects, such as memory impairment and mood changes.
3. Glutamine Rebound
Alcohol influences neurotransmitter systems in the brain, including glutamate receptors and the glutamate signaling pathway. Glutamine (a precursor to glutamate) temporarily increases with drinking alcohol, leading to higher energy levels. After alcohol consumption is completed, the glutamate receptors in the brain sense reduced glutamine signaling, leading to increased glutamine production, or so called “glutamine rebound.” This frequently occurs during deep sleep, stimulating the brain and often causing drinkers to wake up earlier than their body would like. Disrupted sleep is a major cause of fatigue the next morning.
4. Vitamin loss and electrolyte loss
Studies have shown that alcohol depletes essential vitamins and electrolytes, which play a major role in the body’s daily functions. Along with using up such nutrients in the metabolic processes required to digest alcohol, the diuretic nature of alcohol also contributes to vitamin and electrolyte loss through urination. After a night of drinking, the resulting lack of key B and C vitamins, as well as potassium, magnesium and zinc can have a devastating effect on the body. B vitamins help regulate the nervous system, form red blood cells, turn food into energy, as well as aid in other important biological processes. Vitamin C is a key antioxidant with a variety of functions, including regulation of blood flow and control of neuroprotective effects. Electrolytes support vital functions in the body, such as nerve reaction, muscle function and blood pressure regulation, and a deficiency may cause fatigue, aching and other hangover-like symptoms.
Tests of the ingredients in our dietary supplement, used in isolation or in combination, have shown efficacy in preventing the four underlying causes of a hangover detailed above.
Helping enzymes break down toxic acetaldehyde
A key part of our original formula stems from a study that provides evidence that sulforaphane (a compound found in cruciferous vegetables such as broccoli) helps eliminate acetaldehyde by inducing the enzyme aldehyde dehydrogenase (ALDH).
Along with sulforaphane, other ingredients in our formula help enzymes eliminate acetaldehyde by boosting glutathione, “the mother of all antioxidants,” an amino acid that protects cells from free radicals and helps neutralize acetaldehyde. However, because glutathione breaks down into amino acids in the stomach, we use glutathione precursors n-acetylcysteine (NAC), vitamin C, and alanyl glutamine to stimulate its production in the body.
We also use NAC to combat acetaldehyde toxicity in the liver. The sulfhydryl renders aldehydes unable to form cross-links, which damage cells. Another study demonstrates how a combination of cysteine, thiamine (a sulfur-containing nutrient depleted by alcohol) and Vitamin C aid in acetaldehyde detoxification.
Preventing overproduction of cytokines
Our hangover product formula also contains anti-inflammatory agents. We use two main ingredients to reduce the inflammatory cytokines that cause sickness-like symptoms. The first, mung bean powder, has been shown to decrease inflammation due to cytokines. The second, epigallocatechin gallate (ECGC), has shown similar results. For mung bean and ECGC, inflammatory cytokine reduction can likely be attributed to their anti-HMGB1 properties.
Balancing glutamine levels
Glutamine stores can be increased by simply ingesting L-alanylglutamine, a dipeptide molecule of glutamine and alanine. Studies have shown that L-alanylglutamine is better absorbed in the body than L-glutamine. Glutamine also acts to stabilize blood sugar levels by suppressing insulin to stop a decline of sugar levels and stimulate glycogen release to increase blood sugar to more normal levels.
Additionally, B vitamins, zinc, and magnesium are thought to deepen REM sleep, which is the important part of sleep that is disrupted by glutamine rebound.
Increasing electrolytes and vitamins
Our blend of vitamins and electrolytes aims to increase these essential nutrients in the body to prepare for the loss resulting from alcohol consumption. In addition to playing important roles in normal biological functions, these vitamins and electrolytes also help prevent a hangover in other ways. In addition to benefiting REM sleep, Zinc, Magnesium and B Vitamins support the alcohol dehydrogenase enzyme that breaks down acetaldehyde. Vitamin C, Magnesium and Zinc also serve as antioxidants, fighting the free radicals that become a problem with alcohol consumption.
Note on Timing:
Our product is designed to be taken before alcohol consumption to allow for complete update of supplements. In addition, studies have shown that ingesting NAC after alcohol consumption could cause liver damage, while NAC taken before alcohol intake may reduce liver damage.